The correct answer is B. Setting up a VPC endpoint for Amazon S3 within the VPC allows Amazon EC2 instances to access the S3 bucket without traffic traversing the internet. This ensures the connection remains within the AWS network, providing a secure and efficient way to access S3 resources. Options A, C, and D would either incorrectly configure DNS, route traffic through the internet/third-party services or set up unnecessary VPN connections, none of which meet the requirement as effectively as a VPC endpoint.