Microsoft Defender for Office 365 primarily focuses on safeguarding against phishing attacks and malicious links in emails, whereas Microsoft Defender for Cloud Apps specializes in monitoring and controlling shadow IT by providing detailed insights into cloud application usage.

Microsoft Defender for Office 365 offers advanced threat protection features such as safe attachments and safe links, along with data loss prevention capabilities. On the other hand, Microsoft Defender for Cloud Apps delivers comprehensive visibility into cloud app usage, risk assessment, and automated policy enforcement to mitigate risks.

Microsoft Defender for Office 365 ensures real-time protection against sophisticated email threats and enables automated investigation and response. Meanwhile, Microsoft Defender for Cloud Apps provides anomaly detection based on user behavior analytics and facilitates compliance with regulatory requirements through detailed reporting.

All of the above features and benefits are accurately described, making the integration of both solutions a comprehensive approach to enhancing the organization's security capabilities, ensuring compliance, and supporting scalability.