Use TLS certificates from AWS Certificate Manager (ACM) with an Application Load Balancer. Deploy self-signed certificates on the EC2 instances. Ensure that the database client software uses a TLS connection to Amazon RDS. Enable encryption of the RDS DB instance. Enable encryption on the Amazon Elastic Block Store (Amazon EBS) volumes that support the EC2 instances.

Use TLS certificates from a third-party vendor with an Application Load Balancer. Install the same certificates on the EC2 instances. Ensure that the database client software uses a TLS connection to Amazon RDS. Use AWS Secrets Manager for client-side encryption of application data.

Use AWS CloudHSM to generate TLS certificates for the EC2 instances. Install the TLS certificates on the EC2 instances. Ensure that the database client software uses a TLS connection to Amazon RDS. Use the encryption keys from CloudHSM for client-side encryption of application data.

Use Amazon CloudFront with AWS WAF. Send HTTP connections to the origin EC2 instances. Ensure that the database client software uses a TLS connection to Amazon RDS. Use AWS Key Management Service (AWS KMS) for client-side encryption of application data before the data is stored in the RDS database.