Create a single VPC and place all resources within it, using security groups to control access.

Create multiple VPCs, each with its own set of security groups and network ACLs, and use AWS Transit Gateway for inter-VPC connectivity.

Create a single VPC and use AWS Direct Connect to establish a secure connection to the on-premises data center.

Create multiple VPCs, each with its own set of security groups and network ACLs, and use VPC endpoints for secure access to AWS services.