The issue described involves the VPC route table not being populated with routes from the first data center location, which is advertising 110 routes. AWS VPC route tables have a limit on the number of routes they can hold, which is 50 routes for a VPC with a virtual private gateway. Since the first location is advertising more routes than this limit, it's causing the routes not to be populated into the VPC route table. The most operationally efficient manner to resolve this issue is to summarize the advertised routes from the routers. This reduces the number of routes being advertised to the VPC, ensuring that the total number of routes does not exceed the VPC route table limit. Therefore, the correct action is to change the router configurations to summarize the advertised routes, which corresponds to option B. Options A, C, and D do not directly address the root cause of the issue in an operationally efficient manner. Option A suggests a complex and unnecessary reconfiguration, option C is not a guaranteed solution as it depends on AWS support and quotas, and option D introduces additional complexity and cost without directly solving the route advertisement issue.