Databricks runs HDFS on cloud volume storage; as such, cloud virtual machines must be deployed in the region where the data is stored.

Databricks workspaces do not rely on any regional infrastructure; as such, the decision should be made based upon what is most convenient for the workspace administrator.

Cross-region reads and writes can incur significant costs and latency; whenever possible, compute should be deployed in the same region the data is stored.

Databricks notebooks send all executable code from the user’s browser to virtual machines over the open internet; whenever possible, choosing a workspace region near the end users is the most secure.